Sildenafil vs. Tadalafil | Comparison Overview

Sildenafil vs. Tadalafil | Overview

Sildenafil and Tadalafil have been around since 2017 and both erectile dysfunction treatments have their ups and downs, along with different outcomes for different people; everyone’s body is different. For those who may not know, Tadalafil is the generic form of Cialis. Whereas Sildenafil is the generic form of Viagra. It’s important to note that there is no chemical difference between the generic drugs and their brand name versions.

Cialis tadalafil vs Viagra sildenafil picture

What’s the difference in how the drugs perform?

The number one difference between the two drugs is how long they last. Tadalafil can last up to 36 hours, which means it should treat your erectile dysfunction anytime within that time frame. Sildenafil only lasts around 4 to 6 hours. For this reason, many people often prefer Tadalafil due to being able to have spontaneity when it comes to sexual interaction. Also, Tadalafil can be taken on an empty stomach or with a meal, it won’t affect the strength of the drug or how quickly it kicks in. On the other hand, Sildenafil should be taken on an empty stomach. Eating before taking Sildenafil can cause the drug to take longer to kick in, especially with fatty meals. Keep in mind, each person has a different biological makeup, one may find that Sildenafil works better for them than Tadalafil, or vice versa. Each drug also has its own list of side effects, which is another reason an individual may have a ED drug preference over the other. Lastly, it’s important to see what drugs interact with Sildenafil and Tadalafil (info included at the bottom) in order to choose which drug is best for you.

Cialis tadalafil vs Viagra sildenafil picture

Side effects of Sildenafil and Tadalafil

It’s important to note that if you are taking either drug and begin to feel symptoms such as chest pain, dizziness, or nausea, or have an erection lasting four or more hours to stop taking the drug and seek medical help immediately. Common side effects of Sildenafil include: headaches, nasal congestion, nausea, dizziness, rash, urinary tract infections, diarrhea, an inability to differentiate between green and blue, facial flushing, and stomach pain. About 15% of people who take this drug will experience one or more side effects. Common side effects of Tadalafil include: headaches, upset stomach, diarrhea, facial flushing, flu-like symptoms, nausea, low blood pressure, blurred vision, changes in visual colors, and abnormal ejaculation. Depending on the severity of the side effects, your doctor may increase or decrease your recommended dosage.

 

What other drugs can interact with Tadalafil and Sildenafil?

Sildenafil increases the effects of blood pressure lowering medications, this includes the blood pressure lowering effects of nitrates. Drugs like this include Isordil (isosorbide dinitrate), imdur, ismo, monoket (isosorbide mononitrate), Nitro-Dur, Transderm-Nitro (nitroglycerin). Drugs that are primarily used for treating angina. If you are taking any of these medications you should not take Sildenafil. Also, some medications can cause increases in the amount of Sildenafil within the body. Drugs like this include: Tagamet (cimetidine), Nizoral (ketoconazole), Erythromycin, Sporanox (itraconazole), Reyataz (atazanavir), Posicor (mibefradil). People taking any of these drugs should be cautious when taking Sildenafil. Lastly, Rifampin is known to decrease the levels of Sildenafil within the blood which will most likely reduce its effectiveness.

Tadalafil, like Sildenafil, also increases the lowering of blood pressure caused by nitrates. Drugs such as Isordil (isosorbide dinitrate), imdur, ismo, monoket (isosorbide mononitrate), Nitro-Dur, Transderm-Nitro (nitroglycerin). Do not take Tadalafil if you are taking any of the above or any nitrates, this could result in heart pain and even heart attacks. Drugs such as Rifampin, Tegretol, Tegretol XR, Equerto, Carbatrol, (carbamazepine), Dilantin, Dilantin-125 (phenytoin), and Phenobarbital can decrease the amount of Tadalafil in your blood, reducing its effectiveness. Certain drugs can cause a decrease in the breakdown, and thus elimination of Tadalafil from the body. If taking any of the below drugs, it’s important to reduce the amount of Tadalafil taken to avoid having your levels of Tadalafil becoming too high. These drugs include Nizoral (ketoconazole), Erythromycin, Sporanox (itraconazole), Crixivan (indinavir), and Norvir (ritonavir). If you are on alpha-blockers, which are primarily used for treating enlarged prostate (BPH) and high blood pressure, it is not recommended that you take Tadalafil. However, if you do, it’s important to start at the lowest dose. This is because Tadalafil will further affect the blood pressure lowering effects of these drugs, such as Hytrin (terazosin). Lastly, both Tadalafil and alcohol lower your blood pressure. Because of this, certain symptoms such as dizziness, headaches, and increased heart rate may be exaggerated by drinking alcohol while taking Tadalafil, and isn’t recommended. It is also important that you do not combine any ED medications with each other (these include all other PDE5 inhibitors) such as vardenafil, levitral, tadalafil, sildenafil, cialis, viagra, avanafil, etc, except on the order of a Doctor and Pharmacist.

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Sources:

https://www.healthline.com/health/erectile-dysfunction/cialis-levitra-viagra

https://www.healthline.com/health/tadalafil-oral-tablet

https://www.drugs.com/sildenafil.html

https://www.medicinenet.com/cialis_vs_viagra/article.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603624/

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Showing 13 comments
  • User

    ERECTION PROBLEM

    • User

      I don’t get hard enough to get in her??

      • Katrina Taylor

        Have you tried any ED medication before? Depending on what state you live in we may be able to ship you the Troche! The Troche is a combination of Generic Viagra and Generic Cialis in a lozenge that goes under your tongue. Since it goes under the tongue, this goes into your bloodstream rather than your digestive system. That and the combination of both medications gives you an increased chance of achieving and maintaining an erection.

    • User

      Help find the one that works best for you

      • Katrina Taylor

        Please give us a call at 1-888-588-8094 and we will help you out!

  • User

    Tengo 70 años no tengo ereccion y no tengo espermatosoides,? Cual me recomienda

    • MyDrHank

      Nuestro medicamento más común es Viagra genérico y Cialis genérico. ¡Llámenos al 888-588-8094 y le ayudaremos a configurarlo!

  • User

    YA PROBE LOS DOS Y ELRRSULTADO ES 60/70 PRRCENT..KE ONDA..SI ESTOY SANO..MY BARBEY ESTA FURIKA ,Y YO ME SIENTO MARAVILLOSAMNTE HORRIBLE..TIENES ALGO MEJOR ..KUAL ES LA SOLUCION TU KE TODO LO SABES..ARRR SSTO URRRG DALEDALE RRRAPID..KONTEXTA..SHLOM..THANKU..

    • MyDrHank

      Dependiendo del estado en el que viva, tenemos la opción de otro medicamento. ¡Llámenos al 888-588-8094 y le ayudaremos a configurarlo!

  • User

    I’m 65 and I’ve tried both pills they didn’t work for my system.The only onethat did the trick was an injection (TryMix.How can you help Dr?

    • Katrina Taylor

      We also carry A Troche which is a medicated lozenge that dissolves in the mouth that contains a combination of Tadalafil 40mg and Sildenafil 200mg in four-quadrant lozenges. This is designed to be separated into four separate doses, that can allow the patient to try a combination of two different Erectile Dysfunction medications instead of taking 2 pills. By placing it under the tongue and keeping it there until fully dissolved and absorbed by the salivary glands. Unlike a tablet that travels via the stomach, the troche goes directly into the bloodstream causing a more efficient and effective result. This delivery method helps to avoid the medication going through the digestive process.

  • User

    After prostatectomy 6 years ago then radiation treatment 3 years ago and now radiation scanning. Lupron injections to keep my PSA .049 & testosterone at castration . Im disabled what works for me now ? I was prescribed tri-mix .
    Eric

    • Katrina Taylor

      Hello! Thank you for your comment. I can’t guarantee what medication is going to be effective for you. However, we do carry A Troche. This is a medicated lozenge that dissolves in the mouth that contains a combination of Tadalafil 40mg and Sildenafil 200mg in four-quadrant lozenges. This is designed to be separated into four separate doses, that can allow the patient to try a combination of two different Erectile Dysfunction medications instead of taking 2 pills.

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